POEMS Syndrome

A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)

Also Known As:

Syndrome, POEMS; Syndrome, Crow-Fukase; Polyneuropathy Organomegaly; Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome; Crow Fukase Syndrome; Organomegalies, Polyneuropathy; Organomegaly, Polyneuropathy; Polyneuropathy Organomegalies; Syndrome, Takatsuki's; Takatsuki Syndrome; Crow-Fukase Syndrome; Takatsuki's Syndrome

Nervous System Diseases: 14737
- Neuromuscular Diseases: 2048
  - Peripheral Nervous System Diseases: 11768
    - Polyneuropathies: 5219
      - POEMS Syndrome: 777
Hemic and Lymphatic Diseases: 7
- Hematologic Diseases: 3445
  - Blood Protein Disorders: 17
    - Paraproteinemias: 3515
      - POEMS Syndrome: 777
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Congenital Abnormalities: 26404
  - Multiple Abnormalities: 213
    - POEMS Syndrome: 777
Immune System Diseases: 4430
- Immunoproliferative Disorders: 29
  - Paraproteinemias: 3515
    - POEMS Syndrome: 777

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Disease

Drug/Important Bio-Agent (IBA)